Amygdala; Neuropharmacology; Neurophysiology; Social Behavior; Prefrontal Cortex; Psychiatry and Psychology
How do we interact with others, and why?
Our brains evolved to deal with increasing demands of dynamic social interactions. Social behaviors are heavily reinforcement driven, whether their motivating factors are physical rewards, such as food and sex, or more abstract rewards, such as vicarious experience and interpersonal reputation. Investigating how the brain computes social preferences and decisions can offer an ecologically valid and efficient way of unlocking the mystery of the mind. Elucidating the neural basis of social behavior will ultimately help treat social deficits in numerous psychiatric disorders.
Our research is aimed at understanding the neural mechanisms responsible for social cognition. Our laboratory focuses on how reward-related areas of the brain signal social preferences and generate social decisions. To answer our questions, we apply both neurophysiological and neuroendocrinological approaches during social interactions. We investigate neuronal representations as well as neuromodulator actions (e.g., oxytocin, serotonin) in the reward-related brain regions during social behavior. In a subset of topics, we also investigate similar neural processes using neuroimaging techniques.
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- Neural mechanisms of social interaction and social decision-making
- single-unit recording from the prefrontal cortex and the amygdala
- neurobiology of oxytocin-mediated social cognition
- combined neurophysiology and neuropharmacology
- neuroethology of social behavior
- reference frames and sensory-to-motor transformation
Oxytocin Under Opioid Antagonism Leads to Supralinear Enhancement of Social Attention
Dal Monte O*, Piva M*, Anderson KM, Tringides M, Holmes AJ, Chang SWC. (2017) Proc. Natl. Acad. Sci., 114, 5247-5252. (*equal contributions)
Live Interaction Distinctively Shapes Social Gaze Dynamics in Rhesus Macaques
Dal Monte*, O., Piva*, M., Morris, J. A., & Chang, S. W. (2016) J. Neurophys., 116, 1626 –1643. (* equal contributions)
The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others
Apps, M. A., Rushworth, M. F., & Chang, S. W. (2016) Neuron, 90(4), 692-707.
Neural mechanisms of social decision-making in the primate amygdala
Chang, S. W., Fagan, N. A., Toda, K., Utevsky, A. V., Pearson, J. M., & Platt, M. L. (2015) Proc. Natl. Acad. Sci., 112(52), 16012-16017.
Neuronal reference frames for social decisions in primate frontal cortex
Chang SW, Gariépy JF and Platt ML (2013) Nat. Neurosci., 16: 243–250.
Neuroethology of primate social behavior
Chang SW, Brent LJN, Adams GK, Klein JT, Pearson JM, Watson KK, and Platt ML (2013) Proc. Natl. Acad. Sci., 110, 10387–10394.
Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta)
Chang SW, Barter JW, Ebitz RB, Watson KK and Platt ML (2012) Proc. Natl. Acad. Sci., 109, 959–964.
Idiosyncratic and systematic aspects of spatial representations in the macaque parietal cortex
Chang SW and Snyder LH (2010) Proc. Natl. Acad. Sci., 107, 7951–7956.
Using a compound gain field to compute a reach plan
Chang SW, Papadimitriou C, and Snyder LH (2009) Neuron, 64, 744–755.
Full List of PubMed Publications
- Barack DL, Chang SWC, Platt ML: Posterior Cingulate Neurons Dynamically Signal Decisions to Disengage during Foraging. Neuron. 2017 Oct 11. PMID: 29024659
- Chang SWC: An Emerging Field of Primate Social Neurophysiology: Current Developments. eNeuro. 2017 Sep-Oct; 2017 Oct 4. PMID: 29085898
- Turrin C, Fagan NA, Monte OD, Chang SWC: Social resource foraging is guided by the principles of the Marginal Value Theorem. Sci Rep. 2017 Sep 12; 2017 Sep 12. PMID: 28900299
- Dal Monte O, Piva M, Anderson KM, Tringides M, Holmes AJ, Chang SWC: Oxytocin under opioid antagonism leads to supralinear enhancement of social attention. Proc Natl Acad Sci U S A. 2017 May 16; 2017 May 1. PMID: 28461466
- Dal Monte O, Piva M, Morris JA, Chang SW: Live interaction distinctively shapes social gaze dynamics in rhesus macaques. J Neurophysiol. 2016 Oct 1; 2016 Jul 13. PMID: 27486105
- Apps MA, Rushworth MF, Chang SW: The Anterior Cingulate Gyrus and Social Cognition: Tracking the Motivation of Others. Neuron. 2016 May 18. PMID: 27196973
- Chang SW, Calton JL, Lawrence BM, Dickinson AR, Snyder LH: Region-Specific Summation Patterns Inform the Role of Cortical Areas in Selecting Motor Plans. Cereb Cortex. 2016 May; 2015 Mar 15. PMID: 25778345
- Chang SW, Fagan NA, Toda K, Utevsky AV, Pearson JM, Platt ML: Neural mechanisms of social decision-making in the primate amygdala. Proc Natl Acad Sci U S A. 2015 Dec 29; 2015 Dec 14. PMID: 26668400
- Du E, Chang SW: Neural components of altruistic punishment. Front Neurosci. 2015; 2015 Feb 9. PMID: 25709565
- Chang SW, Isoda M: Toward a better understanding of social learning, social deciding, and other-regarding preferences. Front Neurosci. 2014; 2014 Nov 6. PMID: 25414637
- Chang SW, Platt ML: Amygdala: eyes wide open. Curr Biol. 2014 Oct 20; 2014 Oct 21. PMID: 25442845
- Chang SW, Platt ML: Oxytocin and social cognition in rhesus macaques: implications for understanding and treating human psychopathology. Brain Res. 2014 Sep 11; 2013 Nov 11. PMID: 24231551
- Chang SW: Coordinate transformation approach to social interactions. Front Neurosci. 2013; 2013 Aug 21. PMID: 23970850