Pradeep Kotapurathu kurup, PhD

Associate Research Scientist in the Child Study Center

Research Organizations

Child Study Center: Lombroso Lab

Research Summary

My research focuses on the role of STriatal Enriched Protein tyrosine phosphatase (STEP) in higher order brain functions such as learning and memory and its implications in neuronal disorders.

Selected Publications

  • Abeta-mediated NMDAR endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP. Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn A, Lombroso PJ (2010) Abeta-mediated NMDAR endocytosis in Alzheimer’s disease involves ubiquitination of the tyrosine phosphatase STEP. J Neurosci 30:5948-5957.
  • Genetic reduction of the tyrosine phosphatase STEP reverses cognitive and cellular deficits in a mouse model of Alzheimer’s disease. Zhang YF, Kurup P, Xu J, Carty N, Fernandez S, Nygaard HB, Pittenger C, Greengard P,Strittmatter S, Nairn AC, Lombroso PJ (2010) Genetic reduction of the tyrosine phosphatase STEP reverses cognitive and cellular deficits in a mouse model of Alzheimer’s disease. PNAS 107: 19014-19019. (F1000 cited article)
  • The Role of STEP in Alzheimer’s Disease Kurup P, ZhangYF, Venkitaramani DV, Xu J, Lombroso PJ (2010) The Role of STEP in Alzheimer’s Disease. Channels 4:347-350.
  • Reduced levels of the tyrosine phosphatase STEP block beta amyloid-mediated GluA1/GluA2 receptor internalization. Zhang YF, Kurup P*, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ (2011) Reduced levels of the tyrosine phosphatase STEP block beta amyloid-mediated GluA1/GluA2 receptor internalization. J Neurochem. 2011 Aug 28. doi: 10.1111/j.1471-4159.2011.07450.x. (*equal first author and corresponding author)
  • Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP Xu J, Kurup P, Zhang Y, Goebel-Goody SM, Wu PH, Hawasli AH, Baum ML, Bibb JA, Lombroso PJ (2009) Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. J Neurosci 29:9330-9343.
  • Striatal-enriched Protein- tyrosine Phosphatase (STEP) Regulates Pyk2 Kinase Activity Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ (2012). Striatal-enriched Protein- tyrosine Phosphatase (STEP) Regulates Pyk2 Kinase Activity.J Biol Chem. 287(25):20942-56.
  • The tyrosine phosphatase STEP: Implications in Schizhophrenia and the molecular mechanism underlying antipsychotic medications.

    Carty N, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ (2012) The tyrosine phosphatase STEP: Implications in Schizhophrenia and the molecular mechanism underlying antipsychotic medications. Transl Psychiatry (PMID: 22781170).

  • The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation Zhang Y, Venkitaramani DV, Gladding CM, Kurup P, Molnar E, Collingridge GL, Lombroso PJ (2008) The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. J Neurosci 28:10561-10566.
  • STriatal Enriched Protein tyrosine phosphatase in Alzheimer’s Disease Xu J, Kurup P, Nairn AC, Lombroso PJ (2012) STriatal Enriched Protein tyrosine phosphatase in Alzheimer’s Disease. Adv Pharmacol. (in press)
  • Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

    Xu J, Hartley BJ*, Kurup P*, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho S-M, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman PA, Rapoport J, Ellman JA., Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Mol Psychiatry. 2016 Oct 18. doi: 10.1038/mp.2016.163.2016 PMID: 27752082

  • Inhibitors of the Tyrosine Phosphatase STEP Reverse Cognitivedeficits in a mouse model of Alzheimer’s disease model Xu J, Chatterjee M, Baguley, TD, Brouillette J, Kurup P, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Nairn AC, Tautz L, Ellman JA, Lombroso PJ (2014) Inhibitors of the Tyrosine Phosphatase STEP Reverse Cognitivedeficits in a mouse model of Alzheimer’s disease model. PLoS Biology e1001923.
  • STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease Kurup P, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC (2015) STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease. PNAS 112: 1202-7.

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Contact Info

Pradeep Kotapurathu kurup, PhD
Mailing Address
Yale Child Study Center230, South Frontage Road
New Haven, CT 06519

Lombroso lab