Paul J Lombroso MD

Elizabeth Mears and House Jameson Professor in the Child Study Center and Professor of Neurobiology and of Psychiatry; Director, Laboratory of Molecular Neurobiology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Neuroscience

Yale Medical Group

Office of Student ResearchInterdepartmental Neuroscience ProgramNeurobiologyChild Study Center: Tourette’s Syndrome & Obsessive-Compulsive Disorders; Family, Genetic and Molecular Research; NIMH Research Training Program in Childhood-onset Neuropsychiatric Disorders; Albert J. Solnit Integrated Training Program; Child & Adolescent Psychiatry Training Program; Albert J. Solnit Integrated Training | Psychiatry

Research Interests

Translational Neuroscience; Identification of small molecule inhibitors of STEP; Child and adolescent psychiatry; Neuropharmacology more...


  • B.A., Harvard College, 1972
  • M.D., Albert Einstein College, 1975

Selected Publications

  • Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Onomenyi C, Foscue E, Anderson GM, Gressack J, Cuny GD, Glicksman MA, Greengard P, Lam T, Nairn AC, Tautz L, Ellman JA, Lombroso PJ (2014) Inhibitors of the tyrosine phosphatase STEP reverse cognitive deficits in a mouse model of Alzheimer’s disease. PLoS Biology 12(8):e1001923. doi: 10.1371/journal.pbio.1001923. PMCID4122355
  • Chiodi V, Mallozzi C, Fan Chen J, Ferrante A, Lombroso PJ, Di Stasi AM, Domenici MR, Popoli P (2014) Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP. Neuropsychopharmacology. 39:569-578 PMCID3895235
  • Baguley TD, Xu HC, Chatterjee M, Lombroso PJ, Ellman J (2013) Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of Striatal-Enriched Protein Tyrosine Phosphatase. J Med Chem 56:7636-7650. PMCID in progress.



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